Back to Innovation Lab
Dec-2018-Aged-garlic-extract-supplementation-modifies-inflammation-and-immunity-of-adults-with-obesity-A-randomized-double-blind-placebo-controlled-clinical-trial.pdf (693 KB)

Summary:

Background:

Obesity is a serious global health issue and often results in low-grade systemic inflammation, increasing the risk for several chronic diseases. If obesity-induced inflammation could be reduced, fewer complications and co-morbidities might occur.

Objective:

To investigate whether daily supplementation with aged garlic extract (AGE) could reduce chronic inflammation and improve immune function in adults with obesity.

Methods:

Fifty-one healthy adults with obesity (mean age 45.6 ± 1.6 years, mean BMI 36.1 ± 0.9 kg/m2) were recruited to participate in a parallel, double-blind, placebo-controlled, randomized study. After being matched by BMI, participants were randomized into the AGE supplementation or placebo group. Participants were asked to take a divided daily dose of 3.6 g AGE or placebo, with food for 6 weeks. Blood lipid and inflammatory markers were assessed at baseline and after 6 weeks of supplementation. Additionally, peripheral blood mononuclear cells (PBMC) were isolated from whole blood and used to detect changes in immune cell populations and levels of cytokine secretion. A one-way ANCOVA was performed to evaluate differences between the two groups, controlling for respective baseline values.

Results:

At the end of study, serum IL-6 (p ¼ 0.04) and TNF-a (p ¼ 0.05) of participants consuming AGE were significantly lower than those consuming the placebo capsules. PBMC flow cytometry results showed that participants from the AGE group had a higher proportion of gd-T cells (p ¼ 0.03) and a lower proportion of NKT cells (p ¼ 0.02) in the total population of lymphocytes. There was no difference in percentage of NK cells between the two groups. A significant difference in blood LDL concentration was also observed (p ¼ 0.05). Total cholesterol and non-HDL cholesterol tended to differ between participants from the AGE group and those from the placebo group, although values did not achieve statistical significance.

Conclusion:

Six weeks of AGE consumption modulated immune cell distribution, prevented the increase of serum TNF-a and IL-6 concentrations and reduced blood LDL concentration in adults with obesity. AGE, taken consistently, may be beneficial in preventing the development of chronic diseases associated with low-grade inflammation in adults with obesity.

Changjie Xu, Anne E. Mathews, Camila Rodrigues, Brandon J. Eudy, Cheryl A. Rowe, Alison O’Donoughue, Susan S. Percival